Chronic traumatic encephalopathy (CTE) has been described in the literature as a neurodegenerative disease with: specific neuropathologic characteristics as well as broad and diverse clinical features. Recent reports have suggested a high incidence of this pathology among post mortem samples in former professional contact sport athletes and military service members. Some of the pathological findings reported in the literature may be encountered with age and other neurodegenerative diseases. Recent reports suggested a strong associated between repetitive brain injury and CTE. Yet the relationship of the pathology to the clinical profile is as yet not clarified and the presentation of recent cases are very similar to other disease process. The role of described tau pathology, especially in small amounts, causing complex changes in behavior such as depression, substance abuse, suicidality, ALS, personality changes, or cognitive impairment is a point of controversy. Physiatrists treating‚ contact‚ sport related‚ athletes and the military. This session will review the pathology, proposed clinical profiles, limitations in the data and pending studies‚ of this highlighted and controversial‚ diagnosis. Course design:1: Overview of the history, epidemiology and pathology of CTE; what have we learned and what is next? 2: Clinical syndromes associated with CTE: what do we know and what is unclear? 3: Next steps in understanding CTE.

Learning Objectives

  • Describe the history and associated pathology of CTE.
  • Discuss specific clinical profiles associated with CTE and describe the controversy regarding risk.
  • List the methods to further define CTE and its clinical profile that are presently underway.